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Our Pipeline

We are building a strong and diversified proprietary pipeline of innovative, single-pill combination therapies in novel and unique dosage strengths, targeting some of the leading causes of death in both developed and developing countries, including hypertension, recurrent intracerebral haemorrhage (stroke), cardiovascular disease and type 2 diabetes. Our most advanced candidate in Phase III development, GMRx2, is a single-pill, triple-combination, in novel and proprietary dosage strengths, for the first-line treatment of hypertension and the prevention of recurrent intracerebral haemorrhage (stroke).

No.4 Fact

Our business model avoids the early, high-risk stages of drug discovery and development, reducing time-to-market, providing a higher probability of success and requiring less capital investment to bring our medicines to patients than is usual in the industry.

The Overview

At George Medicines, we are focused on developing late-stage drugs to improve upon existing treatments of non-communicable diseases through innovative, sustainable, and more patient-friendly methods.

Our innovative pipeline is targeting some of the world’s leading causes of death, including hypertension, recurrent intracerebral haemorrhage (stroke), cardiovascular disease and type 2 diabetes.

By developing best-in-class, existing treatments in innovative single-pill combinations, George Medicines is building a pipeline of future treatments with the potential to be more efficacious, safer, and more affordable than the current alternatives.

We understand the financial burden associated with current medications and the resultant impact on accessibility to regions worldwide. With all our combination therapies in development, accessibility is a core focus regardless of the region.

The George Medicines Pipeline

GMRx2
Phase III
Anticipated Market Launch
2024

GMRx2 is a single-pill, triple combination containing the commonly used hypertension medicines telmisartan, amlodipine and indapamide, in novel and proprietary dosage strengths.

Through this innovative combination we aim to tackle the growing issue of hypertension, one of the leading causes of cardiovascular disease and morbidity, while improving accessibility in key markets across the globe1,2. GMRx2 has the potential to provide an optimal balance of increased efficacy and patient adherence  and reduced side effects compared with current treatments and thereby potentially aiding millions of patients globally.

Two Phase III trials are underway investigating the efficacy and safety of GMRx2 as a first-line treatment for hypertension:

  • An international, multi-center, randomised, double blind, active controlled, parallel group study, evaluating the efficacy and safety of GMRx2 in patients with hypertension compared to dual combinations of the same components. The trial’s primary outcome measure is the change in home systolic blood pressure (SBP) from baseline to week 12. The trial is enrolling 1,500 patients across sites in seven countries, including the US, UK and Australia (NCT04518293).
  • An international, multi-center, randomised, double blind, placebo controlled, parallel group study in 250 patients across 3 countries (US, Australia and UK), evaluating the safety and efficacy of GMRx2 in patients with hypertension compared to placebo. The primary outcome measure of this trial is the difference in change in home SBP from baseline to Week 4 (NCT04518306).

GMRx2 is also being studied in an investigator-initiated study by The George Institute for Global Health. TRIDENT (Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial) is investigating the effectiveness of more intensive blood pressure-lowering treatment following an intracerebral haemorrhage (ICH) – a stroke caused by ruptured blood vessels in the brain – to prevent recurrent serious cardiovascular events such as stroke.

Acute ICH accounts for at least 10 per cent of the 20 million new strokes in the world each year and ICH survivors are at high risk of recurrent stroke and other cardiovascular events. While numerous studies have proven the benefit of stroke survivors reducing their risk of recurrent stroke through taking blood pressure-lowering medicines, many are either not receiving any blood pressure-lowering medication or they are receiving inadequate control.

TRIDENT is recruiting 4,200 patients with ICH from approximately 150 sites around the world. Learn more about the study here.


GMRx4
Phase II
Anticipated Market Launch
2027

GMRx4 is a single-pill, triple combination of low-dose blood glucose lowering medicines, being investigated as a treatment for those with type 2 diabetes, which accounts for around 90% of those diagnosed with diabetes mellitus. Worldwide, approximately 460 million adults are living with diabetes, which is expected to grow to 700 million by 2045. Type 2 diabetes is characterised by insulin resistance where the body does not fully respond to insulin, resulting in the rise of blood glucose and further rise in insulin release. This process can exhaust the pancreas resulting in reduced insulin production causing higher blood sugar levels. With GMRx4, we aim to reduce blood glucose levels while reducing the number of medicines required with current treatments.


References

1Murray CJL, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M, et al. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1223-49.
2The Blood Pressure Lowering Treatment Trialists’ Collaboration. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. The Lancet. 2021;397(10285):1625-36.
3Chow CK, Teo KK, Rangarajan S, et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013;310(9):959-68.
4Fryar CD, Ostchega Y, Hales CM, Zhang G, Kruszon-Moran D. Hypertension prevalence and control among adults: United States, 2015–2016.
5Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018:ehy339-ehy.